This project is part of an international collaboration which aims to determine the structure of S glycoprotein (spike) at high resolution by electronic cryomicroscopy. The results will shed light on the particularities of the interaction between SARS-CoV-2 and its receptor, which could explain its high infectivity. Furthermore, we will analyse images of spike complexes with neutralizing human antibodies from patients who have overcome the disease, thus providing important information for the design of therapeutic strategies.
Principal Investigators: José María Carazo, Carlos Óscar Sánchez-Sorzano
COVID-19 Project. Centro Nacional de Biotecnología (CNB)-CSIC