With the goal of guiding the design of antibodies, antiviral compounds and other molecular tools to combat COVID-19, X-ray crystallography, electron cryomicroscopy and correlative cryomicroscopy techniques are being used to understand the structure of the virus, its components and the infection process. In addition, work is currently underway to design chimeric viral pseudo-particles from SARS-CoV-2 antigenic regions to validate their potential to generate a protective response to SARS-CoV-2.
Principal Investigators: José María Valpuesta, José Ruiz Castón, Jaime Martín Benito, Carmen San Martín, Mark van Raaij
COVID-19 Project. Centro Nacional de Biotecnología (CNB)-CSIC