Identify inflammatory mediators involved in lung blood-vessel rupture in severe COVID patients.
The project aims to identify which cytokines participating in the inflammatory storm induced by Sars-CoV2 affect the pulmonary endothelial barrier, causing edema in the most severe cases. The group has investigated how to protect the body from systemic inflammation —which have many similarities to inflammation caused by the coronavirus— and have obtained results using a compound that modulates the activity of the RhoA subfamily of GTPases, capable of reducing pulmonary edema. Therefore, a proposal has been put forward to create a platform available for other research groups wishing to test new therapies that strengthen the human lung microvasculature against infection, without the need to resort to animal models directly. The proposal will also contribute to unveiling new treatments that strengthen the circulatory system in order to control vascular hyperpermeability.
Principal Investigator: Jaime Millán (CBM)