The aim of this project is to generate the SARS-CoV-2 virus in the laboratory by assembling synthetic DNA fragments and removing the genes responsible for virulence from its genome with reverse genetics techniques to introduce attenuating mutations and obtain non-infective and highly immunogenic derivatives as SARS-CoV-2 vaccine candidates. In parallel, animal models (transgenic mice) are being developed for the validation of vaccines and other therapeutic agents against COVID-19.
Principal Investigators: Luis Enjuanes, Isabel Sola, Sonia Zúñiga
COVID-19 Project. Centro Nacional de Biotecnología (CNB)-CSIC